abstract：BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...

journal_title：Neuropsychobiology

authors： Van Den Bossche MJ,Docx L,Morrens M,Cammaerts S,Strazisar M,Bervoets C,Smolders S,Depreeuw V,Lenaerts AS,De Rijk P,Del-Favero J,Sabbe BG

更新日期：2012-01-01 00:00:00

abstract：:The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhanc...

journal_title：Neuropsychobiology

authors： Jobert M,Wilson FJ,Ruigt GS,Brunovsky M,Prichep LS,Drinkenburg WH,IPEG Pharmaco-EEG Guidelines Committee.

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...

journal_title：Neuropsychobiology

authors： Monteleone P,Tortorella A,Scognamiglio P,Serino I,Monteleone AM,Maj M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 w...

journal_title：Neuropsychobiology

authors： Kang EH,Park JE,Lee KH,Cho YS,Kim JJ,Yu BH

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Research into the significance of early subjective response to antipsychotic medication has so far only involved observation periods of up to 1 year. METHOD:The Drug Attitude Inventory (DAI-10) questionnaires, completed by patients with the diagnosis of schizophrenia in 1997-1998, were the bases for this ...

journal_title：Neuropsychobiology

authors： Murawiec S,Boutros NN

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...

journal_title：Neuropsychobiology

authors： Giegling I,Porcelli S,Balzarro B,Andrisano C,Schäfer M,Möller HJ,Rujescu D,Serretti A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:In general, humans tend to discount the value of delayed reward. An increase in the rate of discounting leads to an inability to select a delayed reward over a smaller immediate reward (reward-delay impulsivity). Although deficits in the serotonergic system are implicated in this reward-delay impulsivit...

journal_title：Neuropsychobiology

authors： Demoto Y,Okada G,Okamoto Y,Kunisato Y,Aoyama S,Onoda K,Munakata A,Nomura M,Tanaka SC,Schweighofer N,Doya K,Yamawaki S

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology. This trial examines whether quality of sleep the night prior to surgery can be improved by opipramol and whether this effect is dose dependent. A second objective of this study is to exam...

journal_title：Neuropsychobiology

authors： Hueppe M,Hartge D,Stoll KD,Ros A,Schmucker P,Gerlach K

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Valproic acid or valproate (VA) is an anticonvulsant and mood-stabilizing drug primarily used in the treatment of epilepsy and bipolar disorder. Ziprasidone (ZPN) is an atypical antipsychotic drug used mainly for the treatment of schizophrenia. METHODS:This study is a part of our investigation on the c...

journal_title：Neuropsychobiology

authors： Karapidaki I,Ekonomopoulou MT,Akritopoulou K,Anestakis D,Iakovidou-Kritsi Z

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...

journal_title：Neuropsychobiology

authors： Schecklmann M,Schenk E,Maisch A,Kreiker S,Jacob C,Warnke A,Gerlach M,Fallgatter AJ,Romanos M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paravent...

journal_title：Neuropsychobiology

authors： Park SW,Choi SM,Lee JG,Lee CH,Lee SJ,Kim NR,Kim YH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Considerable evidence suggests that variation of the serotonin-transporter-linked promoter region (5- HTTLPR) is associated with anxiety-related traits. Academic outcomes are also more closely related to trait anxiety. This preliminary study aimed to explore the association between academic performance and l...

journal_title：Neuropsychobiology

authors： Calapoğlu M,Sahin-Calapoğlu N,Karaçöp A,Soyöz M,Elyıldırım UY,Avşaroğlu S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Many studies have examined the effects of cerebrovascular changes on treatment response in geriatric depression. However, few such studies have examined the relationship between cerebrovascular changes and long-term prognosis. We examined the effects of cerebrovascular changes on the course of geriatric depre...

journal_title：Neuropsychobiology

authors： Yamashita H,Fujikawa T,Takami H,Yanai I,Okamoto Y,Morinobu S,Yamawaki S

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND/AIMS:Heschl's gyrus (HG) is functionally involved in the genesis of auditory verbal hallucinations (AVH). This dysfunction seems to be structurally facilitated. The aim of the study was to analyze macrostructural features of HG in a group of patients reporting AVH who demonstrated white matter diffusion tens...

journal_title：Neuropsychobiology

authors： Hubl D,Dougoud-Chauvin V,Zeller M,Federspiel A,Boesch C,Strik W,Dierks T,Koenig T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-r...

journal_title：Neuropsychobiology

authors： Kang JI,Kim SJ,Namkoong K,An SK

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide ...

journal_title：Neuropsychobiology

authors： Gałecki P,Florkowski A,Bieńkiewicz M,Szemraj J

更新日期：2010-01-01 00:00:00

abstract：:It has been 60 years since Cade first described patients who responded to antimanic lithium treatment. Two decades later, responders to lithium stabilization emerged in larger numbers. The responses of many severely ill bipolar patients to lithium were striking and called for an explanation. Remarkable reactions to a ...

journal_title：Neuropsychobiology

authors： Grof P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:We have investigated the efficacy of high-frequency left (HFL) versus low-frequency right (LFR) repetitive transcranial magnetic stimulation (rTMS) in depression, focusing on specific symptoms as possible predictors of outcome for these two different types of stimulation. METHOD:Seventy-four outpatients wit...

journal_title：Neuropsychobiology

authors： Rossini D,Lucca A,Magri L,Malaguti A,Smeraldi E,Colombo C,Zanardi R

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...

journal_title：Neuropsychobiology

authors： Dimpfel W,Hoffmann JA

更新日期：2010-01-01 00:00:00

abstract：:Cortisol has a modulatory influence on cognitive functions in humans. Both impairing and enhancing effects of cortisol administration have been shown for hippocampus-dependent declarative memory, and impairing effects have been shown for prefrontal-cortex-dependent working memory function. Given the high density of gl...

journal_title：Neuropsychobiology

authors： Kumsta R,Entringer S,Koper JW,van Rossum EF,Hellhammer DH,Wüst S

更新日期：2010-01-01 00:00:00

abstract：:In a double-blind, placebo-controlled, multiple-ascending-dose study, the encephalotropic and psychotropic properties of ABIO-08/01, a new potentially anxiolytic and nootropic isoxazoline, were studied in 16 young healthy males. In a randomized nonbalanced phase 1 study, they received 3 oral drug doses (10, 20, 40 mg)...

journal_title：Neuropsychobiology

authors： Saletu-Zyhlarz GM,Anderer P,Wolzt M,Semlitsch HV,Assandri A,Nessi P,Nannipieri F,Rosini S,Saletu B

更新日期：2009-01-01 00:00:00

abstract：:The prevalence of 3,4-methylenedioxymethamphetamine (MDMA) use has increased globally and the pattern of consumption has changed considerably. Previously, a subculture of MDMA users was fairly restricted to the dance club scene. More recently, use has spread outside of this subculture and now many users consume MDMA f...

journal_title：Neuropsychobiology

authors： Schenk S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...

journal_title：Neuropsychobiology

authors： Wirgenes KV,Djurovic S,Agartz I,Jonsson EG,Werge T,Melle I,Andreassen OA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) is polymorphic, and may be involved in the pathogenesis and clinical expression of schizophrenia. This study aimed to investigate the frequency of specific APOE genotypes and alleles in a schizophrenic Arab population and evaluate the association of specific APOE types with clinical p...

journal_title：Neuropsychobiology

authors： Akanji AO,Ohaeri JU,Al-Shammri SN,Fatania HR

更新日期：2009-01-01 00:00:00

abstract：:The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...

journal_title：Neuropsychobiology

authors： Deslandes A,Moraes H,Ferreira C,Veiga H,Silveira H,Mouta R,Pompeu FA,Coutinho ES,Laks J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Lithium augmentation is a first-line strategy for depressed patients resistant to antidepressive therapy, but little is known about patients' subsequent long-term course or outcome predictors. We investigated long-term outcomes of unipolar depressed patients who had participated in a study on the effects of ...

journal_title：Neuropsychobiology

authors： Adli M,Bschor T,Bauer M,Lucka C,Lewitzka U,Ising M,Uhr M,Mueller-Oerlinghausen B,Baethge C

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Memory processes, as reflected by 'old/new' effects of event-related potentials (ERPs), have been shown to be impaired in depressed patients. This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been sh...

journal_title：Neuropsychobiology

authors： Zhang Y,Rothermundt M,Peters M,Wiesmann M,Hoy L,Arolt V,Emrich HM,Dietrich DE

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...

journal_title：Neuropsychobiology

authors： Iijima M,Osawa M,Nishitani N,Iwata M

更新日期：2009-01-01 00:00:00

abstract：AIMS:The aim was to measure the prefrontal cortical activity involved in shifting spatial attention to visual stimuli in the left or right visual field using near-infrared spectroscopy. METHODS:Eleven participants performed a simple vigilance task, an endogenous attention task and an exogenous attention task. In the e...

journal_title：Neuropsychobiology

authors： Takahashi M,Ikegami M

更新日期：2008-01-01 00:00:00

abstract：:Neurobiological and pharmacological research has suggested that dysregulation of the central noradrenergic systems might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD. T...

journal_title：Neuropsychobiology

authors： Cho SC,Kim JW,Kim BN,Hwang JW,Park M,Kim SA,Cho DY,Yoo HJ,Chung US,Son JW,Park TW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Structural brain changes and cognitive impairments have been identified as indicators of genetic risk for schizophrenia. However, the pattern of associations between such structural and functional liability markers has been less well investigated. METHODS:Magnetic resonance imaging data and cognitive assess...

journal_title：Neuropsychobiology

authors： Habets P,Krabbendam L,Hofman P,Suckling J,Oderwald F,Bullmore E,Woodruff P,Van Os J,Marcelis M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Previous functional neuroimaging studies have reported that patients with schizophrenia show reduced prefrontal activation during cognitive tasks whereas patients with schizotypal personality disorder (SPD) show preserved or even increased right prefrontal activation, compared to healthy controls; on th...

journal_title：Neuropsychobiology

authors： Hori H,Nagamine M,Soshi T,Okabe S,Kim Y,Kunugi H

更新日期：2008-01-01 00:00:00

abstract：:Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present...

journal_title：Neuropsychobiology

authors： Okugawa G,Nobuhara K,Takase K,Kinoshita T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intrain...

journal_title：Neuropsychobiology

authors： Kudielka BM,Fischer JE,Metzenthin P,Helfricht S,Preckel D,von Känel R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...

journal_title：Neuropsychobiology

authors： Stadler C,Zepf FD,Demisch L,Schmitt M,Landgraf M,Poustka F

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The availability of tobacco products is associated with the likelihood that adolescents will begin using tobacco. Yet the relationship between nicotine availability and voluntary consumption has not been tested experimentally in developing rats. METHOD:The impact of environmental availability on adolescent ...

journal_title：Neuropsychobiology

authors： Biondolillo KD,Pearce AR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:In depressed patients, overstimulation of the hypothalamo-pituitary-adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the most consistent neurobiological finding. Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans. METHODS:We exa...

journal_title：Neuropsychobiology

authors： Himmerich H,Zimmermann P,Ising M,Kloiber S,Lucae S,Kunzel HE,Binder EB,Holsboer F,Uhr M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT le...

journal_title：Neuropsychobiology

authors： Amsterdam JD,Newberg AB

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Previous results indicated a facilitated transcallosal inhibition via the corpus callosum (CC) in alexithymic male students. This study investigates transcallosal inhibition in alexithymic and nonalexithymic psychiatric inpatients. METHOD:Transcallosal inhibition was elicited by means of transcranial magneti...

journal_title：Neuropsychobiology

authors： Richter J,Möller B,Spitzer C,Letzel S,Bartols S,Barnow S,Willert C,Freyberger HJ,Grabe HJ

更新日期：2006-01-01 00:00:00

abstract：:Alcohol-dependent patients face a substantial risk of relapse after detoxification. Though psychosocial stress and coping strategies are regarded as major contributing factors in returning to drinking, the direct effects of coping styles on relapse are not clear. In this treatment outcome study, a mixed gender sample ...

journal_title：Neuropsychobiology

authors： Walter M,Gerhard U,Duersteler-MacFarland KM,Weijers HG,Boening J,Wiesbeck GA

更新日期：2006-01-01 00:00:00